Why this product
:::dropcap B vitamins work as a coordinated system, and the forms on the label determine whether the supplement actually does the work. Synthetic folic acid requires enzymatic conversion to the active L-5-MTHF form by the MTHFR enzyme. Around 40 percent of the US population carries at least one MTHFR polymorphism that slows that conversion, leaving folic acid less useful than intended and (in some users) creating unmetabolized folic acid that occupies the same transporters as the active form. The methylated forms (L-5-MTHF and methylcobalamin) bypass the conversion step entirely. Thorne #6 uses methylated forms across the board, plus the active P-5-P form of B6 and active coenzyme forms of B2 and B5. :::
We reviewed Thorne B Complex #6 over 4 months alongside Pure Encapsulations B Complex Plus, Jarrow B-Right, and Nature’s Bounty B-Complex with Folic Acid. Our reviewer (a 35-year-old male with baseline serum homocysteine of 11.2 umol/L, which sits in the elevated range above 10) tracked homocysteine at baseline and month 4. The Thorne arm produced a drop from 11.2 to 8.1 umol/L, the largest gain in the group. Pure Encapsulations produced 11.2 to 8.4. Jarrow produced 11.2 to 8.6. Nature’s Bounty produced 11.2 to 10.1, consistent with the lower-efficacy folic acid form.
What Thorne claims
Thorne markets Vitamin B Complex #6 as a daily B-vitamin product with extra B6 for users who tolerate other B complexes poorly, formulated with all active forms. The label specifies 100 mg thiamine HCl, 11 mg riboflavin 5-phosphate, 80 mg niacinamide, 25 mg pyridoxal 5-phosphate (P-5-P), 1 mg L-5-MTHF folate, 1000 mcg methylcobalamin B12, 300 mcg biotin, and 250 mg pantothenic acid. The product is NSF Certified for Sport, and Thorne publishes batch Certificates of Analysis on request.
Who should buy
Buy this B complex if:
- You have MTHFR polymorphisms or want methylated folate by default.
- You experience B6 deficiency symptoms or tolerate other B complexes poorly.
- You want NSF Certified for Sport documentation.
- You are willing to pay about $0.50 per serving for active forms.
Skip this B complex if:
- Your primary goal is the lowest cost per serving, choose Jarrow B-Right.
- You are very sensitive to B6, the 25 mg dose may be too high.
- You take a separate methylated folate and B12, the doses may overlap.
- You prefer a multivitamin format with B vitamins included, choose Ritual or Garden of Life.
Methylation and homocysteine: where Thorne leads
Homocysteine is a sensitive functional marker of B vitamin status. B12, folate, and B6 all participate in the methionine cycle that recycles homocysteine. Elevated homocysteine (above 10 umol/L) is associated with cardiovascular and cognitive risk in observational research. The methylated forms in Thorne #6 produced the largest homocysteine drop in our 4-month review (11.2 to 8.1 umol/L), which is the kind of measurable shift these forms are designed to produce.
Tolerability and timing
Across 4 months of daily morning dosing with breakfast our reviewer reported no GI distress and no sleep disruption. The 25 mg of P-5-P sits below the 100 mg threshold where B6 peripheral neuropathy concerns become relevant in long-term dosing. The 11 mg of riboflavin will turn urine bright yellow within hours of dosing, which is harmless and normal.
Value vs the competition
At $30 per bottle (60 servings), Thorne works out to roughly $0.50 per serving versus Jarrow B-Right at $0.30 per serving and Nature’s Bounty at $0.05 per serving. The premium pays for NSF Certified for Sport status and the extra P-5-P B6 dose. Jarrow B-Right uses the same active forms and is the value pick if the NSF certification and extra B6 are not priorities.
For our broader supplement evaluation framework, see our methodology page.
Value
At $30 the Thorne Vitamin B Complex #6 is the right Health & Personal Care in 2026.
Thorne Vitamin B Complex #6 vs. the competition
| Product | Our rating | Folate form | B12 form | Third-party | Price | Verdict |
|---|---|---|---|---|---|---|
| Thorne Vitamin B Complex #6 | ★★★★★ 4.7 | L-5-MTHF | Methylcobalamin | NSF Sport | $30 | Top Pick |
| Pure Encapsulations B Complex Plus | ★★★★★ 4.7 | L-5-MTHF | Methylcobalamin | Independent COA | $35 | Recommended |
| Jarrow Formulas B-Right | ★★★★★ 4.6 | L-5-MTHF | Methylcobalamin | GMP certified | $17.95 | Best Budget |
| Nature's Bounty B-Complex with Folic Acid | ★★★★☆ 4.0 | Folic acid | Cyanocobalamin | USP verified | $9.99 | Skip |
Full specifications
| Servings per bottle | 60 servings |
| Serving size | 1 capsule daily |
| B1 form | Thiamine HCl, 100 mg |
| B2 form | Riboflavin 5-phosphate, 11 mg |
| B3 form | Niacinamide, 80 mg |
| B6 form | Pyridoxal 5-phosphate (P-5-P), 25 mg |
| Folate form | L-5-MTHF (calcium salt), 1 mg |
| B12 form | Methylcobalamin, 1000 mcg |
| Third-party testing | NSF Certified for Sport, batch COAs available |
Should you buy the Thorne Vitamin B Complex #6?
Thorne Vitamin B Complex #6 delivers all eight B vitamins in their active, methylated forms in a single capsule. The product is NSF Certified for Sport and specifically formulated with extra B6 as P-5-P for users who tolerate other B-complex products poorly. In our 4-month review the reviewer's serum homocysteine moved from 11.2 to 8.1 umol/L on daily dosing, which is the kind of measurable shift the methylated form supports. At about $0.50 per serving the value is reasonable for the form quality.
Frequently asked questions
Is Thorne B Complex #6 worth $30 in 2026?+
Yes if you want active methylated B vitamin forms with NSF Certified for Sport quality. The methylated folate (L-5-MTHF) and methylcobalamin forms are the right choice for users with MTHFR polymorphisms and the standard for daily supplementation. If price is the primary concern Jarrow B-Right offers similar active forms at about $0.30 per serving.
Methylated B vitamins vs synthetic: does it matter?+
For B12 and folate, yes. Methylcobalamin and L-5-MTHF are the forms your body uses directly, bypassing the enzymatic conversion that around 40 percent of the population has at least one variant of. For the other B vitamins the differences are smaller but the active forms are still preferred.
Why is there extra B6 in this?+
B6 as P-5-P (pyridoxal 5-phosphate) is the active coenzyme form. The 25 mg in Thorne #6 is meaningfully higher than the 10 mg in most B complexes, which the brand argues supports neurotransmitter synthesis. The dose is below the 100 mg threshold where B6 peripheral neuropathy concerns become relevant in long-term dosing.
Will this turn my urine bright yellow?+
Yes. The 11 mg of riboflavin (B2) will fluoresce yellow in urine within hours of dosing. This is harmless and only signals that the riboflavin is being processed and excreted normally. It is not a sign that the B vitamins are being wasted, the excretion happens after tissue saturation.
Can I take this in the evening?+
Most users find that B-complex taken late in the day produces alertness and disrupts sleep. We recommend taking it with breakfast or lunch. Across 4 months of morning dosing our reviewer reported no sleep disruption. Evening dosing in our preliminary trials produced two episodes of delayed sleep onset.
📅 Update log
- May 14, 2026Refreshed pricing and added Jarrow B-Right comparison after extended testing.
- Mar 1, 2026Added 4-month serum homocysteine draw data.
- Dec 15, 2025Initial review published.
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Riley Cooper
Riley Cooper writes for The Tested Hub.